医学遗传学系
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王墨林
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王墨林

副教授,硕士生导师

电话:0531-88382190

Email: wml@sdu.edu.cn

学习和工作经历:

20059-至今 山东大学医学院遗传学系副教授

20037-20058 山东大学医学院遗传学系讲师

20128-20139 美国Creighton大学博士后

20088-20091 美国加州大学圣迭戈分校(UCSD)访问学者


20037 上海第二医科大学 生化和分子生物学 理学博士

20007 山东医科大学 生化和分子生物学专业 理学硕士

19977 潍坊医学院麻醉系 医学学士

学术兼职:

中国遗传学会教育教学委员会委员;

中国优生协会基因诊断与精准医学分会常务委员,副秘书长。

教学与教材方面:

承担临床医学专业五年制、5+3及留学生、研究生医学遗传学理论及实验课程的教学。2005年被评为医学院优秀青年教师;山东大学2013-2014学年青年教师课堂教学比赛 优秀奖2015年山东省第二届本科高校教师微课教学比赛“三等奖”;2020年全国高等院校遗传学网课教学比赛“一等奖”。全国高等学历继续教育十三五规划教材“医学遗传学(第4版)” 编委;全国高等学校十三五规划教材“医学生物学(第9版)”编委。

教研方面:

主持教研项目:

1. “打造雨课堂支持下的对分课堂,建立‘医学遗传学’课程的新型教学模式”(山东大学教育教学改革研究项目2020Y179

2. “基础医学专业研究生课程思政建设改革与探索”(齐鲁医学院研究生教育教学研究项目2020Y21

3. “融入‘翻转’元素的新型‘混合’教学模式在医学基础课程本科教学中的应用”(山东大学齐鲁医学院本科教学改革与研究项目qlyxyj-201715

4.“《医学遗传学》理论课教学内容、教学方法的优化与改革”(山东大学教学改革项目,2010-2011.

发表教研论文:

1. 思政元素融入“医学遗传学”教学的方法与路径探析. 国际遗传学杂志. 2020,43(6), 375-377

2. 王墨林. 融入翻转元素的新型混合教学模式在医学遗传学教学中的应用. 国际遗传学杂志. 2018,41(3), 177-179

3. 王墨林. 医学遗传学实验教学改革的探索与实践。基础医学研究,2011,131):34-35

4. 王墨林. 医学遗传学教学内容与方法改革初探.高等院校遗传学教学改革探索(张飞雄,李绍武主编),化学工业出版社. 2010.81-83


科研方向:

遗传病致病基因功能研究

主持科研课题:

1. 黄芩素通过ER-α36对胶质瘤的抑制作用及机制研究  山东省自然科学基金面上项目(ZR2017MH053)

2. 新型雌激素受体ER-α36在雌激素抗神经炎症及神经保护中的作用及机制研究  国家自然科学基金专项基金(31240031

3. 紫檀芪与新型雌激素受体ER-α36对阿尔采默病的神经保护作用研究 山东省自然科学基金青年基金(ZR2012HQ016)

4. 神经靶酯酶在神经退行性疾病中的作用及机制研究 国家自然科学基金青年基金 30500190

代表性科研论文(第一或通讯*):

1. Wang Y, Pan X, Li Y, Wang R, Yang Y, Jiang B, Sun G, Shao C, Wang M*, Gong Y*. CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. J Pathol. 2021 Feb 27. doi: 10.1002/path.5657. Online ahead of print.

2. Pan X, Zhao B, Song Z, Han S, Wang M*. Estrogen receptor-α36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cells. J Pharmacol Sci. 2016 Feb;130(2):85-93.

3. Yin L, Pan X, Zhang XT, Guo YM, Wang ZY, Gong Y, Wang M*. Downregulation of ER-α36 expression sensitizes HER2 overexpressing breast cancer cells to tamoxifen. Am J Cancer Res. 2015 Jan 15;5(2):530-44.

4. Han S, Zhao B, Pan X, Song Z, Liu J, Gong Y, Wang M*. Estrogen receptor variant ER-α36 is involved in estrogen neuroprotection against oxidative toxicity. Neuroscience. 2015 Dec 3;310:224-41.

5. Song Z, Han S, Pan X, Gong Y, Wang M*. Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways. J Pharm Pharmacol. 2015 May;67(5):720-30.

6. Song Y, Wang M*, Mao F, Shao M, Zhao B, Song Z, Shao C, Gong Y*. Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish. Dis Model Mech. 2013 Mar;6(2):404-13.

7. Jia L, Liu J, Song Z, Pan X, Chen L, Cui X, Wang M*. Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. J Pharm Pharmacol. 2012 Oct;64(10):1510-21.

8. 刘晶,宋珍,潘晓华,陈亮,崔行,王墨林*.牛蒡低聚果糖对脂多糖诱导下RAW264.7细胞炎症模型的抗炎作用. 山东大学学报(医学版). 2012,50(12):41-46

9. 贾立云, 潘晓华, 刘晶, 崔行, 王墨林*. 人参皂苷Rb1ReAβ_(25-35)诱导SK-N-SH细胞损伤的保护作用.山东大学学报(医学版). 2011,49(4):33-37

10. Wang ML, Yan JB, Xiao YP, Huang SZ. Construction of an allogenic chimeric mouse model for the study of the behaviors of donor stem cells in vivo. Chin Med J (Engl). 2005 Sep 5;118(17): 1444-50.





Molin Wang

Associate Professor, Supervisor of master students

Tel0531-88382190

Email: wml@sdu.edu.cn


Biography

Professional Experience

2005 - Present Associate Professor, Department of Genetics, School of Basic Medical Science, Shandong University.

2003 -2005 Lecture, Department of Genetics, School of Basic Medical Science, Shandong University.

2012- 2013 Postdoctoral fellow, Creighton University, USA.

2008 - 2009 Visiting scholar, UCSD, USA


Education

Ph.D., Biochemistry and Molecular biology, Shanghai Second Medical University, 2003

M.S., Biochemistry and Molecular biology, Shandong Medical University, 2000

Bachelor of Medicine, Anaesthesiology, Weifang Medical College, 1997


Courses:

1. Medical Genetics for undergraduates

2. Molecular Genetics for graduates

3. Genomics for graduates

4. Human Genetics (English) for MBBS


Academic and social work

Committee member of Education and Teaching Committee in Genetics Society of China

Standing committee member of Genetic Diagnosis and Precision Medicine Branch in China Healthy Birth Science Association

Research interest

Exploring the function of genes responsible for genetic diseases

Research projects

1. Research on the role of baicalein on glioma through ER-α36, Natural Science Foundation of Shandong Province (ZR2017MH053).

2.  The role of ER-α36 in estrogen anti-neuroinflammation and neuroprotection, NSFC (31240031).

3. Research on the neuroprotective effects of pterostilbene and ER-α36 on Alzheimer's disease, Natural Science Foundation of Shandong Province (ZR2012HQ016).

4. Research on the action and mechanism of neuropathy target esterase on neurodegenerative diseases, NSFC (30500190).


Publications

1. Wang Y, Pan X, Li Y, Wang R, Yang Y, Jiang B, Sun G, Shao C, Wang M*, Gong Y*. CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. J Pathol. 2021 Feb 27. doi: 10.1002/path.5657. Online ahead of print.

2. Pan X, Zhao B, Song Z, Han S, Wang M*. Estrogen receptor-α36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cells. J Pharmacol Sci. 2016 Feb;130(2):85-93.

3. Yin L, Pan X, Zhang XT, Guo YM, Wang ZY, Gong Y, Wang M*. Downregulation of ER-α36 expression sensitizes HER2 overexpressing breast cancer cells to tamoxifen. Am J Cancer Res. 2015 Jan 15;5(2):530-44.

4. Han S, Zhao B, Pan X, Song Z, Liu J, Gong Y, Wang M*. Estrogen receptor variant ER-α36 is involved in estrogen neuroprotection against oxidative toxicity. Neuroscience. 2015 Dec 3;310:224-41.

5. Song Z, Han S, Pan X, Gong Y, Wang M*. Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways. J Pharm Pharmacol. 2015 May;67(5):720-30.

6. Song Y, Wang M*, Mao F, Shao M, Zhao B, Song Z, Shao C, Gong Y*. Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish. Dis Model Mech. 2013 Mar;6(2):404-13.

7. Jia L, Liu J, Song Z, Pan X, Chen L, Cui X, Wang M*. Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. J Pharm Pharmacol. 2012 Oct;64(10):1510-21.

8. Wang ML, Yan JB, Xiao YP, Huang SZ. Construction of an allogenic chimeric mouse model for the study of the behaviors of donor stem cells in vivo. Chin Med J (Engl). 2005 Sep 5;118(17): 1444-50.




 
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