Research:
Genomic instability in somatic cells and its role in tumorigenesis
Selected Publications:
1. Mitotic recombination produces the majority of recessive fibroblast
variants in heterozygous mice٬Proc. Natl. Acad. Sci. USA., 1999,
96:9230
2. Chromosome instability contributes to loss of heterozygosity
in mice lacking p53, Proc. Natl. Acad. Sci. USA. , 2000, 97:7405
3. Mitotic recombination is suppressed by chromosomal divergence
in hybrids of distantly related mouse strains, Nature Genetics,
2001, 28:169-172
4. Loss of heterozygosity and point mutation at Aprt locus in T
cells and fibroblasts of Pms2-/- mice, Oncogene, 2002, 21:2840.
5. Somatic recombination redux, Nature Genetics, 2003, 33: 5-6.
|